Keywords
kidney
Kinshasa University Clinic
Nganda Center
National Institute for Biomedical Research
How to Cite
Abstract
Introduction
Renal biopsy (Renal Puncture Biopsy, RPB) is essential for the diagnosis and prognosis of kidney disease. However, it is rarely performed in African countries, particularly in French-speaking regions, despite its importance for assessing disease progression and guiding treatment.
Purpose
To determine the epidemiological and histopathological profiles of kidney biopsies in Kinshasa from 2020 to 2022.
Methods
This retrospective cross-sectional study was conducted across various laboratories in Kinshasa and covered the period from January 2020 to December 2022.
Results
Among the 1,642 biopsies performed between 2020 and 2022 at Kinshasa University Clinic (KUC), Nganda Center (NC), and the National Institute for Biomedical Research (NIBR), only 51 were renal biopsies, representing 2% (n = 51). The most represented age group was 38–47 years (35%). Men accounted for 67.7% of cases. Nephrotic syndrome was the most common clinical indication (39.2%). Segmental and focal hyalinosis predominated histologically, accounting for 45.1% of cases.
Conclusions
Although infrequent in our setting, renal biopsies remain indispensable when kidney disease is suspected. They constitute a critical tool in the nosological, diagnostic, and therapeutic approach to nephrology for the effective management of kidney disease.
References
Chalouhy, C. E. (2017). Renal biopsy technique. Drug & Disease. Retrieved May 15, 2024, from [Google Scholar].
Diallo, D., et al. (2019). Epidemiology of kidney diseases in West Africa: A biopsy-based study. African Journal of Nephrology, 22(1), 15–22.
Diamniadio. (2025). Kidney disease will become the fifth leading cause of death in Africa in 2040. APIDPM Tropical Health Press. Retrieved May 15, 2024, from https://apidpm.com
Djarou, S., et al. (2021). Epidemiology and histopathological patterns of renal biopsies in Sub-Saharan Africa: A review of 5 years at the University Hospital of Bamako. African Journal of Nephrology, 16(2), 102–110.
En-Nya, F., Bouattar, T., Hajar, B., et al. (2017). Ponction-biopsie rénale: Indications et résultats à propos de 549 biopsies rénales. Néphrologie & Thérapeutique, 14, 335–402. https://doi.org/10.1016/j.nephro.2017.08.179
Hautemanière, A., et al. (2018). Épidémiologie des maladies glomérulaires en France: Analyse des biopsies rénales. Néphrologie & Thérapeutique, 14(6), 452–460.
Kabongo Mpolesha, J.-M. (2013). Syllabus of special anatomy pathology (1st doctorate). University of Kinshasa, Faculty of Medicine.
Kouadio, T., et al. (2020). Renal biopsy in Sub-Saharan Africa: Experience from Côte d'Ivoire. Nephrology Dialysis Transplantation, 35(3), 578–584.
Li, L.-S., & Liu, Z.-H. (2004). Epidemiologic data of renal diseases from a single unit in China: Analysis based on 13,519 renal biopsies. Kidney International, 66, 920–923. https://doi.org/10.1111/j.1523-1755.2004.00837.x
Mbanya, D., et al. (2018). Histopathological features of renal biopsies in Sub-Saharan Africa. Journal of Nephropathology, 22(4), 265–270.
Mbarki, H., Belghiti, K. A., Harmouch, T., et al. (2016). Ponction biopsies rénales dans le Service de Néphrologie de Fès: Indications et résultats à propos de 51 cas. Pan African Medical Journal, 24(1), 21. https://doi.org/10.11604/pamj.2016.24.21.3982
Nasr, S. H., et al. (2013). Trends in kidney biopsy findings in the United States, 1996–2010. Clinical Journal of the American Society of Nephrology, 8(10), 1632–1641.
Nseka, N. M. (n.d.). Notes de cours de néphrologie (1st doctorate). University of Kinshasa, Faculty of Medicine.
Oluseyi, A., et al. (2017). Pattern of renal disease in Nigeria based on biopsy data. African Journal of Nephrology, 20(2), 85–92.
Renaloo. (2024). WHO must finally prioritize kidney disease in global public health strategies. Retrieved May 15, 2024, from https://renaloo.com/loms-doit-enfin-prioriser-les-maladies-renales-dans-les-global-public-health-strategies
Rivera, F., et al. (2020). Spanish registry of glomerulonephritis: A 20-year perspective. Nefrología, 40(5), 564–573.
Sano, M., et al. (2021). Clinical presentation of renal biopsy: A retrospective study in Japan. Nephrology Journal, 29(1), 12–18.
Stengel, B., et al. (2017). Gender differences in renal biopsy: A study of 10,000 cases. Nephrology Reviews, 41(3), 87–92.
Sumaili, E. K., Krzesinski, J.-M., Cohen, E. P., & Nseka, N. M. (2010). Épidémiologie de la maladie rénale chronique en République démocratique du Congo: Une revue synthétique des études de Kinshasa, la capitale. Néphrologie & Thérapeutique, 6(4), 232–239. https://doi.org/10.1016/j.nephro.2010.03.008
Tayebi, M., et al. (2019). Epidemiology and histopathology of renal biopsies in Tunisia: A 10-year study. Journal of Nephrology, 32(1), 45–53.
University of Geneva. (2022). Kidney diseases in question. Private Foundation of the University Hospitals of Geneva. Retrieved May 15, 2024, from https://fondationhug.org/les-maladies-renales-en-question
Whittier, W. L., & Korbet, S. M. (2004). Timing of complications in percutaneous renal biopsy. Journal of the American Society of Nephrology, 15(1), 142–147. https://doi.org/10.1097/01.asn.0000102472.37947.14
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